What does it do?

Gut inflammation & symptoms

Lab researchCommunity

Lab research: Cell and mouse colitis experiments investigate anti-inflammatory activity.1

Community: Community reports often include simultaneous BPC-157, which prevents clear attribution.6

Molecular information

3

Amino-acid sequence

  1. Lys
  2. Pro
  3. Val

3 residues · N → C3

Length3 amino acids
Molecular weight · Da342.43 Da
Molecular formulaC16H30N4O43

Free-base specification; acetate adds acetic acid. Amidated KPV is chemically distinct and should not be silently substituted.

Pharmacokinetics

Unverified reference estimateNot independently confirmed
Reference half-life30 min12
Route / formulationSource page: Injectable. Exact PK route not verified.

Secondary-source estimate shown for this route; the population and exact formulation have not been independently matched to a human PK study. The source’s clearance label is approximately five half-lives, not zero remaining drug or a duration of effects.

Illustrative half-life model for KPV: Pep-Pedia estimate · InjectableNormalized terminal-phase decline, not measured blood concentration or effect duration. Five half-lives leaves 3.125%. 0%50%100%030 min1 h1.5 h2 h2.5 h1 half-life
50%of reference level

Illustrative scenario using an unverified reference estimate.

About 3% remaining after 2.5 h

Five half-lives in this estimated model. This is not a prediction of when effects stop.

About this estimate

Population: Not established by the reference estimate

Source’s stated attribution: Limited data

Source’s reported peak time: 3 min. This has not been independently confirmed and is not used in the elimination curve.

100 × 2−time / half-life. Time zero is a reference level, not the moment of administration. Absorption, repeated dosing, metabolites and clinical effects are not modeled. Five half-lives leaves 3.125%, not zero. This curve cannot determine a dosing interval.

What to expect

Study outcomes

Preclinical anti-inflammatory signal

KPV reduced inflammatory signaling in cells and improved experimental mouse colitis measures. Human clinical benefit remains untested in the cited study.1

Additional research

At 100 μg/mL, cultured-cell lipid readouts decreased. Oral administration in high-fat-diet mice changed weight gain and lipid measures; no human metabolic benefit is established.4

Reported timelines

Reference & community

Days 1–3; weeks 1–3; 4–8

Source reports progressively reduced symptoms; not a validated clinical response timeline.13

These are reported timelines, not a prediction of your response.

Doses & schedules

11 rows
Route

Scroll to compare all columns →

One row for each documented route and dose or dose range
RouteDoseFrequencyGoal / evidenceDurationReferences
SubQ200-300 mcgOnce dailyGeneral Anti-InflammatoryReference report4-8 weeks13
SubQ250 mcgTwice dailyActive InflammationReference report4-8 weeks13
SubQ500 mcgOnce dailyAutoimmune SupportReference report4-8 weeks13
SubQ500 mcgTwice daily for 1 week then reduceAcute Flare-upsReference report4-8 weeks13
Oral200 mcgTwice dailyMild Gut InflammationReference report4-12 weeks13
Oral300-500 mcg3 times dailyIBD/IBSReference report4-12 weeks13
OralOral with meals500 mcg3 times dailyAcute FlaresReference report4-12 weeks13
Topical0.1% creamTwice dailyMild InflammationReference reportUse as needed13
OtherAffected areas0.3-0.5% cream2-3 times dailyPsoriasis/EczemaReference reportUse as needed13
IntranasalNasal spray100-200 mcgTwice dailyNasal InflammationReference report4-8 weeks13
IntranasalNasal spray200-300 mcg3 times dailyChronic SinusitisReference report4-8 weeks13

Study and label doses retain their study context. Reference reports are unvalidated practices, not personal treatment instructions. Ranges remain ranges; escalation stages are labeled.

Cycles & timing

Reference reports13

Reported use periods and breaks. These do not establish a safe cycle or prove that breaks prevent tolerance.

Injectable

Use period
4-8 weeks
Break
2-4 weeks to assess baseline inflammation
Reported timing

Can be taken any time; some prefer morning for anti-inflammatory effects

Oral

Use period
4-12 weeks
Break
Optional 2-4 week breaks
Reported timing

With meals for best tolerance, or empty stomach for maximum effect

Topical

Use period
Use as needed
Break
Not required
Reported timing

After cleansing, can be used under moisturizer

Nasal

Use period
4-8 weeks
Break
As needed based on symptoms
Reported timing

Morning and evening, additional dose midday if needed

Animal and cell protocols 1

Laboratory exposures cannot establish a human dose.

2 rows
Route

Scroll to compare all columns →

Animal and cell exposures
RouteDoseFrequencyGoal / evidenceDurationReferences
OralOral (mouse drinking water)Not specifiedNot specifiedExperimental colitis and inflammatory signalingDSS/TNBS mouse models and cultured human-derived cellsAnimalsNot specified1
CellsIn vitro cell exposureNot specifiedNot specifiedExperimental colitis and inflammatory signalingDSS/TNBS mouse models and cultured human-derived cellsCellsNot specified1

Side effects & safety

Human safety gap

FDA identified no human exposure dataset for KPV drug products.

2

Formulation uncertainty

FDA notes inconsistencies in identity information and insufficient impurity characterization in submitted materials.

3

Animal findings have limits

Mouse inflammation results do not quantify human adverse effects or long-term safety.

1

Additional reported cautions

Reference reports13

Safety uncertainty

Source's 'excellent safety' and non-immunosuppression claims exceed established human evidence.

Stop symptoms

Fever/chills, worsening inflammation, severe local reaction, allergy or unusual weakness.

Not a complete safety screen. Discuss health decisions with a qualified clinician.

Combinations & interactions

6 entries

Check cautions and reported pairings. A compatibility claim does not establish that a combination is safe.

Melanotan II

Caution reported

Shared α-MSH origin does not prove redundancy or interaction.13

Reference report · Pep-Pedia label: Use Caution

BPC-157

Unverified pairing

Proposed gut-repair complement.13

Reference report · Pep-Pedia label: Synergistic

TB-500

Unverified pairing

Untested inflammatory pairing.13

Reference report · Pep-Pedia label: Compatible

LL-37

Unverified pairing

Theoretical antimicrobial complement.13

Reference report · Pep-Pedia label: Synergistic

Thymosin alpha-1

Unverified pairing

Untested immune pairing.13

Reference report · Pep-Pedia label: Compatible

GHK-Cu

Unverified pairing

Component-based skin hypothesis.13

Reference report · Evidence context: Synergistic for skin

Reconstitution calculator

Enter your peptide amount and container size. Get a volume and a simple measurement scale.

mg

Total labeled amount of KPV.

mL

Usable capacity of the destination vial or pen cartridge.

1 dial unit = 0.01 mL on the documented V2 model. Confirm your pen’s scale.

Vial examples & blend contents KPV

Listed amounts are packaging examples. Check your actual label.

Reconstitution

No validated clinical preparation

No injectable product instruction is established by the cited research.37

Form and stability matter

FDA distinguishes free-base and acetate materials and notes formulation-dependent degradation and aggregation. Catalog storage claims do not establish clinical stability.3

Research-vial limitation

The 10 mg catalog listing alone does not supply a validated diluent volume or beyond-use date.7

Reference preparation details

Reported handling information, not a validated formulation or instruction to prepare an injectable product.

Injectable

The source reports two examples for a 1 mg vial.

Solvents mentioned
Bacteriostatic water
Reported parameters
1 mL gives 1,000 mcg/mL; 2 mL gives 500 mcg/mL.

Oral

This route tab repeats the injectable 1 mg vial examples.

The repeated text does not establish compatibility or stability for the selected oral, topical or nasal formulation.

Topical

This route tab repeats the injectable 1 mg vial examples.

The repeated text does not establish compatibility or stability for the selected oral, topical or nasal formulation.

Nasal

This route tab repeats the injectable 1 mg vial examples.

The repeated text does not establish compatibility or stability for the selected oral, topical or nasal formulation.

13

Appearance & documentation

Appearance and a purity certificate cannot establish sterility, identity, or suitability for injection.

Reported appearanceHigh purity essentialReported appearanceClear solutionReported appearanceStable peptideReported variationProper pHReported concernVisible particlesReported concernYellow coloration
13

Vial sizes

10mg7

Packaging examples, not a market survey. Approved and research products are not interchangeable.

Storage after mixing

Reconstituted research vials

Pep-Pedia reports these handling limits after mixing. They are not validated stability or sterility limits for your vial.

Injectable

Unverified report13
Refrigerated; temperature not specified · 30–45 days

Oral

Unverified report13
Refrigerated; temperature not specified · 24 hours

Nasal

Unverified report13
Refrigerated; temperature not specified · 14 days

Storage notes

13
Injectable

Refrigerate after reconstitution, stable for 30-45 days

Oral

Keep oral solution refrigerated, use within 24 hours of mixing

Topical

Room temperature, away from heat and light

Nasal

Refrigerate nasal solution, use within 14 days

Storage depends on the formulation, diluent, container, and handling. Follow the specific product label or pharmacist’s instructions.

Pen & syringe measurements

Device units measure volume. Concentration determines the amount in mg.

Open calculator ↗
V2 peptide pen

1 notch = 0.01 mL

Documented 1-unit V2 models

One dial increment
1 unit
Cartridge capacity
3 mL
Maximum setting
60 units · 0.60 mL

Use the numbered dose window. Whole-unit settings only; confirm the specification for your exact model.

U-100 syringe

1 unit = 0.01 mL

100 units = 1 mL

10 units
0.10 mL
30-unit capacity
0.30 mL
50 / 100-unit capacity
0.50 / 1 mL

Read the printed unit scale. A small line may represent 0.5, 1, or 2 units depending on the syringe.

Other measuring tools

Use the mL scale

mL syringes and calibrated pipettes

0.01 mL
10 µL
0.10 mL
100 µL
Amount
mL × mg/mL

Drops, sprays and other pen clicks need their own verified volume per increment. They have no universal conversion.

3 mL is cartridge capacity. It does not mean you must prepare or load 3 mL. The original vial and the pen cartridge are different containers. This reference compares measurement scales; it does not establish product or route compatibility.

Device referencesAVERON V2 specifications ↗SilverLeaf V2 unit reference ↗FDA: syringe unit conversions ↗Specifications checked October 12, 2026.

Evidence limits

View findings →

Human efficacy, absorption, dose-response, and long-term safety.1

4 distinct primary sources or abstracts checked. Evidence may concern a parent compound, individual blend ingredient, animal, or cell model; it does not necessarily establish a benefit for this exact product.

Evidence definitions →

Research findings

Preclinical

Source context

Compatibility and synergy labels are source claims, not combination trials; source ratings do not establish comparative efficacy.

Compound identity & other names

A three-amino-acid fragment related to alpha-MSH, studied for inflammatory signaling and intestinal inflammation. Cell and mouse findings have not established a human treatment dose or clinical benefit.

Other names: Lys-Pro-Val · Lysine proline valine · α-MSH fragment · Alpha-MSH fragment

No FDA-approved KPV product.

H-Lys-Pro-Val-OH (KPV)3

How it may work

Proposed intracellular NF-κB modulation; local oral, skin and nasal delivery claims need route-specific evidence.13

Inflammatory signaling changed in cell models

KPV reduced NF-κB/MAPK pathway activation and cytokine secretion in laboratory intestinal and immune cells; PepT1 mediated uptake. These are mechanistic endpoints.

1

Colitis findings were in mice

KPV delivered in drinking water reduced inflammatory measures in DSS- and TNBS-induced mouse colitis. This does not demonstrate treatment of human IBD or validate injection.

1

KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling

At 100 μg/mL, cultured-cell lipid readouts decreased. Oral administration in high-fat-diet mice changed weight gain and lipid measures; no human metabolic benefit is established.

4

Research areas and evidence gaps

Intestinal inflammation research. Cell and mouse colitis experiments investigate anti-inflammatory activity.1

  • Human efficacy, absorption, dose-response, and long-term safety.
  • Whether oral, topical, and injected products produce comparable exposures.

Additional uses listed by Pep-Pedia

Inflammation and immunity. Cytokine, autoimmune/joint and infection-response hypotheses.13

Gut. IBD, IBS, barrier and microbiome claims; not proven disease treatment.13

Skin. Psoriasis, dermatitis and wound models.13

Nasal/respiratory. Sinusitis, allergy and post-viral claims remain experimental.13

Community reports Unvalidated

Self-reports describe gut symptoms and inflammatory complaints. One recent account combined KPV with BPC-157, so effects cannot be assigned to KPV.56

Self-selected accounts, uncertain diagnoses, concurrent compounds, and unverified products prevent causal conclusions.

Search coverage and review status

Additional recent evidence was checked, including KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling. See individual source summaries for findings and limitations.

Checked
2026-10-12
Search
KPV peptide 2025 2026
Catalog
Pep-Pedia ↗ · 4 listed references retained
  • Targeted search, not a systematic or exhaustive review.
  • Retained bibliography entries marked Bibliography only have not been independently verified.
  • Distinct URLs may refer to the same publication; component and formulation boundaries remain important.

AI-prepared summaries. Independent medical editorial review is pending.

Community poll 10 topics · Pep-Pedia snapshot

Voluntary, unverified reports. These percentages do not measure effectiveness or safety.

Primary goal

Recovery/Healing44%
General wellness30%
Anti-aging5%
Fat loss2%
Other: Inflammation 2%

The source hides 38 additional categories. Their labels and percentages are unavailable.

Number of responses to this question: not disclosed.

Source & limitations

The source displays “2773 responses” for this profile. This is not a confirmed participant count or a denominator for individual questions.

  • Voluntary self-reports from Pep-Pedia visitors; identity, treatment, outcomes and timing are unverified. These data are not efficacy or safety estimates.
  • The source displays a profile-wide response label, not a confirmed unique participant count. It stays unchanged across questions. Question-specific denominators and absolute option counts are not exposed.
  • Only the top five categories are displayed for some questions. Extra categories are retained as an undisplayed-category count; their labels and percentages are unavailable.
  • Displayed percentages are rounded. They may not total 100%, especially where categories are hidden.
  • This is a dated snapshot, not a live survey or current recommendation.

References

Original sources and review status. Open a reference to read its summary.

13 sources

1PepT1-mediated tripeptide KPV uptake reduces intestinal inflammationPreclinical · 2008 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

Cell and mouse experiments linked PepT1 uptake to reduced inflammatory signaling and colitis measures. No people were treated; neither human dosing nor injection benefit follows.

Inflammatory signaling changed in cell models

KPV reduced NF-κB/MAPK pathway activation and cytokine secretion in laboratory intestinal and immune cells; PepT1 mediated uptake. These are mechanistic endpoints.

Colitis findings were in mice

KPV delivered in drinking water reduced inflammatory measures in DSS- and TNBS-induced mouse colitis. This does not demonstrate treatment of human IBD or validate injection.

Original source
2FDA: compounding safety concernsRegulator · 2026 · fda.govPrimary source checked
AI-PREPARED SUMMARY

FDA reports no identified human exposure data for KPV-containing drugs.

Original source
3FDA assessment of KPV free base and acetateRegulator · 2026 · fda.govPrimary source checked
AI-PREPARED SUMMARY

Distinguishes the chemical forms, describes quality and formulation uncertainties, and reviews the sparse clinical evidence. This assessment is not an approved product label.

Original source
4KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signalingPreclinical · 2026 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

KPV affected adipogenesis in 3T3-L1 cells and metabolic measures in high-fat-diet mice. Human weight loss was not tested.

KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling

At 100 μg/mL, cultured-cell lipid readouts decreased. Oral administration in high-fat-diet mice changed weight gain and lipid measures; no human metabolic benefit is established.

Additional research · Checked 2026-10-12

Original source
5Pep-Pedia: kpv community protocol referenceCommunity · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

A secondary description of commonly discussed injection schedules, not controlled human evidence.

Original source
6Reddit: experience with KPV and BPC-157Community · 2026 · reddit.comCommunity source checked
AI-PREPARED SUMMARY

One poster reports improved gut symptoms while combining compounds and taking 250–500 mcg KPV nightly. No objective comparison or product verification.

Original source
7Chubby Rabbit Labs KPV 10 mg listingCatalog · 2026 · chubbyrabbitlabs.comCatalog checked
AI-PREPARED SUMMARY

Lists a 10 mg research configuration and states no verified lot-specific documentation is available. Nominal quantity only.

Original source
8Antimicrobial Properties Against Gut Pathogens (2022)Bibliography · 2022 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: The source claims antibacterial selectivity in culture; preservation of an intact human microbiome is not established by such assays.

Reported population / model
In vitro

Reported study details
Multiple bacterial strains · MIC determination

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
9KPV for Psoriasis and Dermatitis (2021)Bibliography · 2021 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: Laboratory skin models reportedly showed a 60% reduction in psoriasis-related markers; no patient clinical efficacy is established by the card.

Reported population / model
Human cells + Animal model

Reported study details
Topical application · 4 weeks

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
10Anti-Inflammatory Mechanisms of KPV (2020)Bibliography · 2020 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: Cell experiments are described as showing reduced NF-κB signaling and inflammatory cytokine transcription.

Reported population / model
In vitro

Reported study details
Various concentrations · Cell culture studies

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
11KPV in Inflammatory Bowel Disease Models (2019)Bibliography · 2019 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: Animal colitis experiments reportedly improved inflammatory and intestinal-barrier measures; human IBD efficacy remains a separate question.

Reported population / model
Animal model

Reported study details
Oral and injection · 14 days · Colitis model

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
12Pep-Pedia: KPV — reported pharmacokineticsReference estimate; not independently verified human PKCommunity · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Lists a half-life of 30 min and a peak time of 3 min. Stated attribution: Limited data. This value is reported by a secondary reference. The stated attribution has not been independently verified as a route- and formulation-matched human PK measurement. Five half-lives is not complete clearance, and the source’s “cleared” value is not used as a measured endpoint.

Secondary reference page checked; the underlying quantitative claim is not independently confirmed. · Checked 2026-10-12

Original source
13Pep-Pedia: KPV — route-specific referenceReference page checked; underlying claims require separate verification.Community · Checked 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Source page checked across available routes. Protocols, cycles, storage, mechanisms and pairing claims are secondary reports; checking the page does not independently validate those claims. Original concise summaries are used here.

Content coverage audit · Checked 2026-10-12

Original source
Source details